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Title: Constructing a bio-health knowledge base for access via a standardised electronic health record prototype
Author: Jing, Xia
ISNI:       0000 0004 2683 8899
Awarding Body: University of Salford
Current Institution: University of Salford
Date of Award: 2009
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Aim and Objectives: To explore the feasibility of accessing biological information and associated health information through a standards-based electronic health record. The objectives include constructing: a condition specific knowledge base prototype; an EHR system prototype based on a standard record architecture; and an interface that connects the two. Method: An ontology was constructed to organise biological and health information in a formal and structured way. Cystic fibrosis was selected as an exemplar condition and the Continuity of Care Record was selected for an EHR prototype application. The sequence variations information and health information in the knowledge base are presented through the EHR prototype's interface and the results are evaluated. Results: A substantive knowledge base prototype of cystic fibrosis was constructed. The content includes: the most common genetic mutations related to cystic fibrosis; time-oriented descriptions of cystic fibrosis; Cochrane conclusions; and gene therapy for cystic fibrosis. The content is organised on both time and problem oriented axes. It was found to be possible to present bio-health information that was case-specific through the EHR prototype interface. Conclusion: Sequence variations information and associated health information can be made accessible through a standards-based electronic health record prototype. Complex knowledge can be accessed, to some extent automatically, thereby providing a starting point for integrating formal and structured biological information within health record systems which can be deployed in clinical settings.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available