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Title: Are ACE I/D and ACTN3 R577X polymorphisms associated with the muscle function of young and older men, and frequent fallers?
Author: McCauley, Tracey
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2009
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Angiotensin Converting Enzyme (ACE) IID, and a actinin 3 (AC1N3) R577X polymorphisms have been linked to the strength and power performance of elite athletes and suggested to influence skeletal muscle function in the general popUlation. This research investigated the association of these two candidate gene polymorphisms with the muscle function of young and older men, and the distribution of these genotypes in frequent fallers compared to controls. Muscle function measurements of young and older men included isometric strength, absolute and relative isokinetic strength at high velocity (ratio of torque at 2400 ·s"; torque at 30°·s") and the time course of an evoked twitch. Additionally body composition was measured by skinfold thickness (young men) and DXA scanning (old men) to estimate fat-free mass, an index of muscularity, and fat mass. ACE and AC1N3 genotypes were determined from whole blood samples using polymerase chain reaction, and serum ACE activity using spectrophotometry. The gemtypes of frequent fallers referred to a Falls Clinic were compared to a control group of healthy men. ACE genotype was not associated with any measure of muscle function, including the time course of an evoked twitch or absolute and relative high velocity torque, or body composition in these populations (ANOVA, 0.12
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: ACE ; AC1N3 ; Age ; Contractile properties ; Frequent fallers ; Muscle strength ; Muscle function