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Title: Highly functionalised fused heterocycle synthesis from fluoropyridines
Author: Cartwright, Matthew William
ISNI:       0000 0004 2680 2490
Awarding Body: Durham University
Current Institution: Durham University
Date of Award: 2006
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Current approaches to drug discovery tends to involve the rapid analogue synthesis and testing of small, focused libraries of low molecular weight, structurally similar "drug-like" molecules, often based around heterocyclic core scaffolds. If some desired activity is shown by a compound, elaboration can give higher activity and more favourable pharmiokinetic properties. As this "lead generation" stage of drug development has been identified as a major bottleneck in the drug pipeline process, there is a great demand for methodology detailing the synthesis of highly functionalised heterocyclic compounds. Our approach involves the sequential nucleophilic aromatic substitution of highly fluorinated pyridines, in an efficient and flexible manner, to furnish a range of novel, functionalised polycyclic systems.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available