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Title: A study of change in human trabecular bone structure with age and during osteoporosis
Author: Jayasinghe, Jayasinghe Arachchilage Premasiri
ISNI:       0000 0004 2680 0946
Awarding Body: University of London
Current Institution: University College London (University of London)
Date of Award: 1991
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The objective of this work was to develop new techniques to view trabecular bone three-dimensionally, and to study its structure and the changes that occur with age and in osteoporosis; the methods used included 3D methods in the SEM, laser confocal microscopy, pseudo-holograms and a "continuous motion parallax method". A detailed analysis of trabecular bone from fourth lumbar vertebral bodies used macro-stereophotographs produced by tilting a sample 10°. Models are proposed for both normal and osteoporotic architecture. A quantitative analysis of the lengths of horizontally oriented trabeculae was carried out. A significant decrease in the number of both vertically and horizontally oriented trabeculae was found. The importance of the influence of different developmental patterns on the formation of the normal structure and of the changing vascularisation on osteoporotic structure are emphasised. Two-dimensional fast Fourier transform methods were employed to study changes in the spatial frequency of trabeculae as a function of orientation. A decrease in spatial frequency was observed in both sexes, but in males this was evident only after the mid-sixth decade in the limited sample studied. Contoured power spectra discriminated different trabecular patterns and the intensity mapping of optical density provided volume density information. Templated reverse transformation was used to study individual orientations of trabeculae. Changes in the quality of trabecular bone with age were also investigated using techniques that analyse bone before and after removal of unmineralised matrix. All specimens were less stiff after removal of osteoid; this was more marked in older specimens. Locally defective mineralisation would explain the changed behaviour observed in some old and osteoporotic specimens. Trabecular fracture patterns had a strong relationship to architecture and microstructure. Scanning electron microscopy was used to study trabecular surfaces. An uncoupling between resorption and formation was evident in older specimens. Two resorption patterns responsible for thinning and perforation and removal trabecular elements were identified. Trabecular microfractures were also investigated.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available