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Title: Targeted delivery of biological agents
Author: Greig, Jenny A.
ISNI:       0000 0004 2680 5966
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2009
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Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector. This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QH301 Biology