Use this URL to cite or link to this record in EThOS:
Title: Segmentation of the Left Atrium and Pulmonary Veins from Contrast-Enhanced MR Images
Author: Karim, Rashed
ISNI:       0000 0004 2680 8796
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2009
Availability of Full Text:
Access from EThOS:
Access from Institution:
Atrial brillation is an important cardiovascular disease causing cardiac malfunction. Theleft atrium and pulmonary veins are the structures most a ected. Radio-frequency catheterablation has now become a standard procedure for correcting atrial brillation. The procedureis minimally invasive and pre-planning the procedure is essential. It is normally required toimage the atrium. Segmentation of the left atrium and pulmonary veins from medical imagesis an important problem and a necessary step for further analysing the left atrium. This dissertation describes techniques for segmenting the left atrium from MR angiographyimages. It also describes methods for extracting sub-atrial structures of the atrium such as thecentral atrial body and pulmonary veins. As pulmonary veins of the left atrium have complexvessel networks, the centrelines of these vessels are extracted allowing for better visualisationand compact representation. Furthermore, the dissertation describes a framework for analysingthe atrium. The pulmonary drainage trees are reconstructed using graph structures. Importantatrial characteristics relevant to catheter ablation procedures are quanti ed. These includeatrial anatomy and ostial diameters. The methods described in the dissertation are evaluated on real patient datasets and comparedagainst manual approaches. A comparative study of the proposed left atrium segmentationalgorithm with an existing approach showed that the proposed approach yields better segmentations. Furthermore, results show that the proposed techniques for pulmonary drainagereconstruction correctly compute and classify atrial anatomy in the majority of cases. Thecomputation of ostial diameters also show close agreement with gold-standard measurements. A series of studies performed to investigate the e ect of user parameters on the quality ofisegmentation and measurements obtained show reproducibility of results. It is envisaged thatthe methods proposed will improve the e cacy of catheter ablation by providing useful andaccurate atrial characteristics and information.
Supervisor: Rueckert, Daniel Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral