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Title: Cyanide and the cystic fibrosis pathogens Pseudomonas aeruginosa and Burkholderia cenocepacia
Author: Ryall, Ben
ISNI:       0000 0004 2680 2992
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2008
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Most cystic fibrosis (CF) sufferers will die before reaching their mid thirties as a result of life long bacterial lung infection. Pseudomonas aeruginosa is the most important respiratory pathogen in CF patients; factors implicated in its pathogenesis include alginate over production, pyocyanin, and extracellular proteases. It is also capable of synthesising hydrogen cyanide, but the role of this potent inhibitor of cellular respiration has not yet been assessed in CF infection. Cyanide concentration was measured in sputum from CF and non-CF bronchiectasis patients with and without P. aeruginosa lung infection using a cyanide ion sensing electrode. Cyanide was detected in sputum from 19/25 patients with current P. aeruginosa infection, whereas it was not detected in any of the 10 patients without this organism (p
Supervisor: Not available Sponsor: Not available
Qualification Name: Not available Qualification Level: Doctoral
EThOS ID:  DOI: Not available