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Title: Pre-clinical evaluation of Bcl-2 inhibitor ABT-737 in small cell lung cancer
Author: Micha, Dimitra
ISNI:       0000 0004 2676 5896
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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The evasion of apoptosis is a common feature of various malignancies and often depends on the overexpression of Bcl-2 family antiapoptotic proteins. Resistance to chemotherapy and radiotherapy is promoted because these tumour cells have a higher threshold for apoptosis-promoting signals than their normal cell counterparts. This has lead to the development of BH3 mimetic compounds that target the survival proteins of the Bcl-2 family.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available