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Title: Mechanism of anti-phagocytosis by YopO, a yersinia type three secretion effector
Author: Groves, Eleanor
ISNI:       0000 0004 2675 8370
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2009
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Pathogenic Yersinia species can avoid phagocytosis by virtue of a type III secretion system that injects protein effectors into host cells, where they hijack phagocytic signalling. YopO is a multi domain protein known to contribute to anti-phagocytosis. It has a N-terminal plasma membrane localisation domain, a serine/threonine kinase activity, a Rho/Rac-family binding domain (RBD) and a C-terminal actin-binding domain. The aim of this study was to understand the previously unknown mechanism of YopO-mediated anti-phagocytosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available