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Title: Beneficial effects of statins on the microcirculation during sepsis
Author: McGown, Caroline Christina
Awarding Body: The University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2009
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Background: Sepsis may be modelled in vivo using lipopolysaccharide (LPS) to cause microvascular disturbances including macromolecular leak and leucocyte adhesion. Such changes may be due to an altered balance of eNOS and iNOS. Statins are widely used to lower cholesterol. Recently evidence indicates statins may exert pleiotropic effects, possibly restoring physiological levels of eNOS and iNOS.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available