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Title: The role of TNF-related apoptosis inducing ligand (TRAIL) in inflammation in vivo
Author: McGrath, Emmet Edward
ISNI:       0000 0004 2679 446X
Awarding Body: The University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2009
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Background:. Neutrophils play a central role in inflammatory disease. Since neutrophil apoptosis is essential for the resolution of inflammation, understanding the mechanisms regulating this process in vivo are important, as is the potential to drive apoptosis using appropriate pro-apoptotic stimuli. Our group previously showed that a death receptor ligand, TRAIL (TNF-related apoptosis inducing ligand), accelerates neutrophil apoptosis in vitro without associated cell activation. This thesis examines the role of TRAIL in inflammation in vivo.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available