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Title: Temozolomide in combination with a novel inhibitor of poly(adp-ribose) polymerase
Author: Jones, Christopher
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Poly(ADP-ribose) Polymerase-1 (PARP-1) is an abundant nuclear enzyme involved in the repair of DNA single-strand breaks via the Base Excision Repair (BER) pathway. Cemozolomide, an alkylating chemotherapy agent with activity in melanoma and gliomas, causes DNA methylation and single-strand breaks that can be repaired by BER. Pre-clinical studies have shown that small-molecule PARP inhibitors can potentiate temozolomide-induced cytotoxicity and anti-tumour activity in vitro and in vivo.
Supervisor: Not available Sponsor: Not available
Qualification Name: Not available Qualification Level: Doctoral
EThOS ID:  DOI: Not available