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Title: Developing viral tools and regulatable gene expression systems to study the dynamics of polyglutamine disease inclusions
Author: Hickman, Matthew Richard
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2009
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Co-chaperone proteins are important mediators of protein triage, deciding whether misfolded proteins should be degraded or refolded. The accumulation of misfolded proteins is thought to be a major contributing factor to polyglutamine diseases, where the expansion of a polyglutamine tract in the disease protein leads to a conformational change in the protein's structure. A major consequence of this misfolding is the formation of intracellular inclusions, which are thought to play an important role in disease pathogenesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Not available Qualification Level: Doctoral
EThOS ID:  DOI: Not available