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Title: Iontophoretic delivery of selected antiparkinsonian agents in vitro
Author: Giller, Tomasz
ISNI:       0000 0004 2678 3197
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2009
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Pharmacological treatment of Parkinson's disease involves frequent dose adjustment, complex dose regimes. Also oral antiparkinsonian drugs suffer from the first pass effect, and a variable absorption in the gastrointestinal tract. The transdermal route is an advantageous alternative, as shown by the recent commercialization of a passive patch containing rotigotine (Neupro®). In this work, transdermal iontophoretic delivery of six drugs was performed, using side-by-side diffusion cells. The best candidates for iontophoretic delivery were pramipexole, selegiline, and piribedil. Trihexyphenidyl, entacapone and pergolide are poor candidates and probably would require patches of impractical size.
Supervisor: Delgado-Charro, Maria Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: iontophoresis ; Parkinson's disease ; transdermal ; skin