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Title: The role of vascular endothelial growth factor in the pathogenesis of amyotrophic lateral sclerosis : a transcriptomic approach
Author: Brockington, Alice R.
ISNI:       0000 0004 2677 5568
Awarding Body: The University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2009
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Recent evidence suggests that the angiogenic factor, vascular endothelial growth factor (VEGF), has a role in determining the survival of motor neurones. VEGF has a pivotal function in the growth of coordinated vascular and neuronal networks in the developing embryo, and promotes the survival of neurones in vitro. Transgenic (VEGFδ/δ) mice which lack a hypoxia-responsive regulatory element in the VEGF gene express low levels of this neurotrophic factor in neural tissue, and develop adult-onset degeneration of motor neurones, which resembles amyotrophic lateral sclerosis (ALS).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Lou Gehrig's disease