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Title: A study of the role of hypoxia in promoting angiogenesis in inflammatory arthritis
Author: Sandhu, Virinderjit
ISNI:       0000 0004 2676 3030
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2009
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In rheumatoid arthritis (RA), formation of new blood vessels (angiogenesis) is required to provide oxygen and nutrients to actively proliferating synovial tissue. The resultant neovasculature s dysfunctional and fails to vascularise the innermost synovium thus perpetuating synovitis. The aim of this thesis was to investigate the relationship between synovial tissue oxygen levels (PO2) and microvascular density in inflammatory arthritis by direct in vivo measurements of PO2 and thus establish whether angiogensisrestores tissue oxygenation through the analysis of Hypoxia-inducible factor (HIF) and Vascular endothelial growth factor (VEGF) which are up regulated in hypoxic conditions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available