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Title: Non-InvasiveStudies into the'Mechanisms ofAtrial Fibrillation
Author: Waktare, Johan E.
ISNI:       0000 0004 2675 5145
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2006
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Atrial fibrillation (AF) is a common arrhythmia which often is difficult to treat. In order to improve therapy, proper understanding of the mechanisms of the condition is vital. This thesis sets out to improve this understanding and contains a series of studies into the mechanisms of AF. The methodology employed in all studies was non-invasive electrocardiographic recording, which allowed data to be recorded in physiological conditions and enabled the determination of clinical events surrounding AF onset in man. The initial work was the study of data contained in a library of Holter recordings collected in patients with paroxysmal AF. Specifically, RR interval files generated from these Holter recordings which had been processed to discriminate sinus rhythm from AF were examined. Prevailing hypotheses regarding arrhythmia initiation, such as the importance of changes in autonomic tone and of short-long-short beat sequences, were tested but found to not be prevalent mechanisms in an unselected population. Atrial ectopy was seen to rise in frequency prior to AF onset, and subsequently was demonstrated to frequently be of apparently uni-focal origin.
Supervisor: Not available Sponsor: Not available
Qualification Name: MD Qualification Level: Doctoral
EThOS ID:  DOI: Not available