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Title: Effects of Glutamine in Neonatal Endotoxaemia
Author: Garrett-Cox, Robin Guy
ISNI:       0000 0004 2677 8996
Awarding Body: University of London
Current Institution: University College London (University of London)
Date of Award: 2008
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Neonatal sepsis increases systemic inflammation, which may lead to multiple organ failure and death. Glutamine has been suggested to have beneficial effects during neonatal sepsis, but its effects on systemic inflammation and systemic metabolism are unknown. Methods: Suckling rat pups were given intraperitoneal endotoxin alone (E) or with glutamine (EG). Controls were administered saline (C) alone or with glutamine (CG). Sepsis score and rectal temperature were monitored. Oxygen consumption (V02, mUkg/h) was measured by indirect calorimetry. Animals were sacrificed exsanguinated and plasma separated. Plasma glutamine and tumour necrosis factor alpha (TNF-u, pg/ml) were measured. Results: Endotoxic (E) rats had lower V02 than C rats from 90 minutes post injection to 210 minutes (V02 150-210 minutes: C 671 +/-45; E 429+1-36, p<0.0004; n=8). V02 was higher (p<0.05) in EG rats than E rats (E 460+1-29; EG 654+1-68; n=10). EG rats were significantly less hypothermic between 90- 210 minutes (58/132 measurements) compared with E (95/147; p=0.0007). Sepsis score was significantly lower in the EG group than the E group (E 4.9+1-0.3; EG 3.6+1-0.3; n=40; p
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available