Asteria monocytogenes is an important pathogen. It can grow over a wide range of temperature conditions (1°C ~ 45°C). The Cold Shock Response is an important part of its growth at low temperature. The Listeria major cold shock protein, encoded by cspla, has been found to act as both Csps and Caps involved in the cold shock response and the promoter of this gene has motifs lormally associated with binding of small DNA binding protein, IHF (Integration Host Factor). In this project the HU homologue, him, was shown to be a real gene by DNA sequence analysis and that hlm protein is produced in L. monocytogenes cells.