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Title: The role of the supramucosal defence barrier in determining the effects of pre-operative radiotherapy on normal neoplastic tissue in patients with rectal cancer
Author: Glancy, Damian Gerard
ISNI:       0000 0004 2677 2906
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2009
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Pre-operative radiotherapy has been shown to reduce the rate of local recurrence following surgery for rectal cancer. However, radiotherapy may increase the risk of anastomotic dehiscence, outweighing any potential oncological benefits. Mucin and trefoil peptides have been shown to be key mediators of epithelial healing and mucosal protection in the colon (including against radiation damage), whilst epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) are also important. Furthermore, all of these proteins become dysregulated in colorectal carcinogenesis and may influence tumour radiosensitivity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available