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Title: The initiation of double-stranded DNA break repair by an AddAB-type helicase-nuclease
Author: Yeeles, Joseph
ISNI:       0000 0004 2677 2674
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2009
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The DNA of all living organisms is constantly damaged by a wide variety of endogenous and exogenous agents. Double-stranded DNA breaks are particularly toxic and under certain conditions a single break will result in cell death. To preserve genome integrity, double-stranded breaks are faithfully repaired via homologous recombination. Recombinational repair in prokaryotes is generally initiated by a class of enzymes known as helicase-nucleases. These enzymes bind tightly to broken duplex DNA ends and use ATP driven motors to unwind the DNA.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available