Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502576 |
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Title: | Pharmacokinetics and pharmacodynamics of anti-tuberculosis chemotherapy | ||||||
Author: | Davies, Geraint Rhys |
ISNI:
0000 0004 2672 5819
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Awarding Body: | University of Liverpool | ||||||
Current Institution: | University of Liverpool | ||||||
Date of Award: | 2008 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
For the first time in thirty years the tuberculosis drug development pipeline may be on the verge of delivering ultra-short course chemotherapy but continued reliance on relapse rates in clinical trials and limited understanding ofthe phenomenon ofpersistence ofM tuberculosis during treatment have made the critical pathway of early clinical development uncertain. It is demonstrated here that serial sputum colony counting,prolonged throughout the first two months oftreatment and analysed using hierarchical non-linear regression techniques has the power to detect treatment differences between combination drug regimens at very modest sample sizes.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.502576 | DOI: | |||||
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