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Title: Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
Author: Collins, Hannah F.
ISNI:       0000 0004 2671 4140
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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The human AIFM2 protein (formerly known as AMID) is an apoptosis associated flavoprotein with a 6-hydroxy FAD cofactor. AIFM2 is a NAD(P)H-binding oxidoreductase with some sequence similarities to A1FM1 (formerly known as AIF, Apoptosis Inducing Factor), a mitochondrion-associated enzyme which relocates to the cell nucleus during apoptosis and Is considered to be a key player in the progression of cell death (1). Uniquely, AIFM2 binds 100% 6-hydroxy FAD as a cofactor. The complete 6-hydroxylation of the FAD cofactor in AIFM2 is auto-catalysed only in the presence of NADPH, and AIFM2 is purified from an E Coli expression system as the completely 6-hydroxylated form, which Is green in colour (2).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available