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Title: C-Myb in the pathogenesis of atherosclerosis
Author: Kelly Ann, Kelly Ann
ISNI:       0000 0004 2670 8621
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated in vitro and in vivo. Knock-down of c-Myb leads to a reduction in proliferation and an increase in apoptosis in vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to reduce the incidence of neointimal formation in vivo by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. Despite these observations, c-Myb expression has not yet been investigated in atherosclerosis. The balance between apoptosis and proliferation is pivotal in the pathogenesis of the disease. The aim of this thesis w as to investigate c-Myb expression in atherosclerotic lesions in addition to elucidating possible mechanisms by which c-Myb functions in atherosclerosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available