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Title: Towards the synthesis of novel upper rim calixsugars
Author: Payerne, Estelle
ISNI:       0000 0004 2669 1946
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2008
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Improvement of cancer treatments is a priority health issue. One approach is to use multivalent scaffolds to prepare drug delivery systems in order to make anti-cancer agents more specific to their target tumours. The aim of this thesis was to design a lectin specific drug delivery system through the preparation of a series of calix[4] sugars suitable for binding with the cell membrane asialoglycoprotein receptor (ASGP-R). Chapter 1 describes the background to this work and focuses on the synthetic methods available for the synthesis and derivatisation of calixarenes with particular emphasis on the preparation of calix[4]sugars. Chapter 2 describes investigations into the incorporation of amino sugars at the upper-rim of calix[4]arene for the synthesis of a series of linked calix[4]sugars. The synthesis of the key intermediate tetra carboxylic acid functionalised calix[4]arene is discussed in detail.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available