The Human Papillomaviruses (HPVs) are DNA tumour viruses that are ubiquitous in the human population. High-risk types, such as 16 and 18 are mainly spread through sexual contact and are associated with a range of clinical conditions, the most important of which is cervical cancer - one of the most frequent malignancies in women. The transforming properties of HPVs are mainly due to the viral E6 and E7 oncoproteins. Previous work In our group used the yeast two-hybrid system to demonstrate a potential interaction between HPV-16 E6 and the SRp25-like protein which serine/arglnine (SR) family of RNA splicing factors.