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Title: Studies on the development and assessment of a novel prostacyclin-eluting stent for the treatment of myocardial ischaemia
Author: ristopher, Christopher
ISNI:       0000 0004 2668 4826
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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Current drug-eluting stents used in the treatment of myocardial ischaemia are unsuitable for all lesion types, and have been associated with endothelial The aim of this work was to develop a novel prostacyclin analogue eluting stent, which would represent a significant advance on existing devices by virtue of a superior biological profile, and optimal release kinetics. The functional effects of leading prostacyclin analogues were assessed on isolated pig coronary and rabbit iliac arteries. AFP07 produced relaxation and contraction in both arteries, whilst cicaprost produced relaxation with no evidence of contraction. Antagonists were used to demonstrate the presence of prostanoid IP receptors mediating relaxation, and contractile EP] and EP3 receptors in each artery bed. Differences in functional responses between analogues were found to be due to differences in activity at E type receptors, with cicaprost being the most selective IP receptor agonist studied.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available