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Title: Gender differences in the cardiovascular effects of cannabinoids
Author: Sherer, Jennifer
ISNI:       0000 0004 2674 9319
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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Gender has been shown to influence the effect of cannabinoids on vascular tone in vitro and cannabinoid metabolism by platelets. The current study examined the influence of gender on the in vivo cardiovascular effects of the cannabinoids and their effect on platelet aggregation. Method and Results: Age-matched anaesthetised male (400-500g) and female (275-290g) rats were treated with anandamide, 1 mg/kg and 3 mg/kg, and HU-21 0, 0.03 ug/kg and 0.1 ug/kg, and changes in heart rate and blood pressure were measured. Anandamide and HU-210 produced hypotension with a greater hypotensive response in male rats compared to females, whereas greater bradycardia in response to anandamide was observed in female rats. Whole blood aggregometry studies were performed in arterial blood taken from male and female rats to examine the aggregatory effects of2-AG, 75 uM, 150 uM and 300 uM and the interaction with 5-HT 10 uM and ADP 1 uM. 2-AG produced concentration- dependent aggregation which was potentiated by 5-HT with a greater response to the lower 2-AG concentration and potentiation by 5-HT in male rats. 2-AG resulted in similar potentiation and prolongation of the response to ADP in male and female rats. The study also examined the effect of the CB I and CB2 antagonists, AM251 and , AM630, on ADP-induced aggregation and it was shown that these receptors are not involved in this aggregation response. Conclusion: The haemodynamic and platelet aggregatory effects of cannabinoids may be influenced by gender. The mechanisms which mediate these gender differences-are yet to be identified.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available