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Title: Biological and chemical characterization of potential antidiabetic principles from selected Nigerian medicinal plants
Author: Shittu, Hafsat
ISNI:       0000 0004 2674 8551
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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Based on ethnobotanical information collected from personally speaking to traditional herbalists in some communities in Nigeria. medicinal plants used in the treatment of diabetes mellitus were collected. Twelve of them were evaluated for acute and sub-chronic hypoglycaemic activity in normal mice following oral administration. These included 75% methanolic extracts of Alchornea cordifolia. Anthocleista vogelii. Cassia nigricans, Cassia sieberiana, Detarium microcarpum, Mitragyna inermis, Nauclea latifolia, Parinaripolyandra, Picralima nitida, Prosopis africana, Pseudocedrela kotschyii and Strychnos spinosa. None of the extracts produced a statistically significant reduction in serum glucose in normal mice after 2 hours. However, four of the extracts (D. microcarpum, P. africana, P. nitida and P. polyandra) produced significant reductions in blood glucose concentrations within weeks; they also produced weight loss or weight stasis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available