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Title: The sphingosine 1 phosphate receptor 5 and sphingosine kinase 1 and 2 are localized in centrosomes : role in regulating cell division
Author: Gillies, Laura
ISNI:       0000 0004 2674 6820
Awarding Body: University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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The bioactive lipid sphingosine-1-phosphate (SIP) has the unique characteristic of being capable of engaging in both paracrine/autocrine signalling and intracrine signalling pathways. Research into the latter has been limited by the failure to identify downstream targets for intracellular S1P. The majority of cellular responses to S1P are mediated by a family of G-protein coupled receptors (GPCR) known as S1P receptors: SIP₁₋₅. The current study demonstrates that SIP₅ and both sphingosine kinases (SPHK1 and SPHK2) exhibit a unique intracellular localization in the centrosome of mammalian cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available