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Title: Functionalisation of nanoparticales for use in DNA bioanalysis
Author: Thompson, David G.
ISNI:       0000 0004 2674 5836
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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This thesis details research into the functionalisation of nanoparticles for deoxyribose nucleic acid (DNA) bioanalysis. The work focuses on combining two techniques; the sequence-specific hybridisation-driven aggregation of noble metal (gold or silver) nanoparticles functionalised with DNA and surface enhanced resonance Raman scattering (SERRS). Oligonucleotide functionalised gold nanoparticles (OGN) are a new and exciting area of research as combining these two moieties leads to novel optical activity. The moieties were synthesised in a repeat of previously published research, their properties fully studied using colorimetry and absorption spectroscopy and unsuccessful attempts made to combine them with SERRS. For the first time, oligonucleotide functionalised silver nanoparticles (OSN) were successfully synthesised and their sandwich assay properties fully studied using colorimetry and absorption spectroscopy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available