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Title: Investigating warfarin variability : the contribution of clinical, genetic, and environmental factors
Author: Al-Zubiedi, Sameh Abdulqader
ISNI:       0000 0004 2674 2686
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2009
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Warfarin is the most widely used oral anticoagulant for the prevention and treatment of various cardiovascular diseases. However, its complications represent an important clinical problem. The drug has a very low therapeutic index and there is significant interpatient and inter-iscmer variability in both pharmacokinetics and pharmacodynamics; these are affected by a large number of genetic and non-genetic factors. Genetic variation in CYP2C9 and VKORCl has been most extensively studied in relation to warfarin dose requirements.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral