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Title: Complement and endotoxins in equine colic
Author: Senior, Jonathan Mark
ISNI:       0000 0004 2674 1739
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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Colic (abdominal pain) is a relatively common disease of horses ranging from mild, transient episodes to a life-threatening syndrome that requires surgical intervention. Equine intestinal abnormalities that involve local stasis are often accompanied by marked proliferation of Gram negative enteric bacteria and breakdown of the mucosal barrier resulting in the transmural and transvascular migration of bacteria and their endotoxins into the circulation (endotoxaemia). Even if the original cause of colic is corrected or resolved, the presence of endotoxaemia can isult in significant morbidity and mortality in horses. This project aimed to characterise specific equine complement component, complement 1 esterase-inhibitor (Cl-inh) because it is considered a key inhibitor of the connplement, coagulation and contact activation pathways.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available