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Title: Identification and characterisation of potential stem cell markers in the gastrointestinal tract in health and following injury
Author: Clyde, Daniel
ISNI:       0000 0004 2674 0533
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2009
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The gastrointestinal tract is in a constant state of renewal mediated by stem cells which are postulated to be located towards the isthmus of gastric glands and the bottom of intestinal crypts. However to date, no definite molecular markers exist ith which to identify these cells and their properties have mostly been inferred from studying the epithelial response to radiation injury. Therefore this thesis aims to assess whether the glycoprotein CD24 is a potential stem cell marker in the gastrointestinal tract, to identify novel candidate stem cell markers using proteomics techniques and to investigate epithelial-mesenchymal interactions during clonogemc cell-mediated epithelial regeneration following radiation injury.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral