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Title: Effects of antimalarial treatments and febrile temperatures on Plasmodium falciparum cytoadherence
Author: Hughes, Katie Ruth
ISNI:       0000 0004 2673 9858
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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The Plasmodium falciparum parasite is thought to be responsible for more than a million deaths every year from severe malaria. Although malaria is a treatable disease, many of the mortalities occur in the first 24 - 48 hours after hospital admission, despite administration of antimalarial drugs. An important contributory factor to severe disease is the ability of the parasite, during the intraerythrocytic development phase, to cause infected red blood cells to sequester in host microvasculature. These sequestered parasitized red blood cells (PRBC) contribute to severe disease by impeding microcirculatory flow and possibly contributing to damage to the host endothelium. Sequestration is a result of the cytoadherence interaction between parasite proteins on the surface of the PRBC, and host endothelial adhesion molecules. Whilst many adhesion receptors have been identified, adhesion to ICAM-1 has been, in some cases, potentially linked with one of the most severe terms ot maiana, cerebral maiaria.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral