Drug profiling, or linking samples of illicit drugs to a common source or synthetic route, has long been a goal of law enforcement. Recently, research has focused on the applicability of isotope ratio mass spectrometry (IRMS) for this task. In this work, MDMA HCl samples were synthesized in-house from the same batch of starting ketone by three reductive aminations (Al/Hg amalgam, NaBH4, and Pt/H2). The resulting MDMA was analysed by IRMS for carbon, nitrogen, hydrogen, and oxygen isotope ratios.