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Title: The development of a novel drug delivery system for the treatment of inflammatory bowel disease
Author: McBride, Eileen
ISNI:       0000 0004 2673 7588
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2008
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The project concerns the development of a drug delivery system for the treatment of inflammatory bowel disease. This condition, which affects more than 2 million people in Europe alone, is characterised by inflammatory lesions which may be confined to the large bowel (ulcerative colitis) or extend through the intestinal tract (Crohn's disease). The components of disease activation lend themselves to treatment with immunomodulators such as the folate analogue methotrexate; although systemic sideeffects are significant. :. To o overcome this limitation, a local delivery system was investigated. In this thesis, folate has been used as a safer surrogate in the development of a silicone ribbon-based oral dosage form.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available