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Title: Novel reactions of organic azides
Author: MacLeod, Fraser
ISNI:       0000 0004 2673 7406
Awarding Body: The University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2009
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The intramolecular Schmidt reaction has emerged over recent years as a valuable method for the synthesis of nitrogen-containing molecules. A recent addition to this field has been made within our group consisting of the rearrangement of epoxy azides that has proved extremely useful for the synthesis of pyrrolidines. The scope of this reaction has been further investigated during the studies leading to this thesis. For example, it has been demonstrated for the first time that substrates containing an electron-rich aryl ring can be employed in this aryl amination protocol (Scheme 1). Additionally, it was also discovered that secondary azides can be utilised in such a reaction, which provides a useful strategy for the incorporation of functionality on the pyrrolidine ring. In the light of the success of these reactions, it was also decided to investigate an analogous strategy could also be employed for the synthesis of piperidine derivatives.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available