Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501635 |
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Title: | Conversion of alcohols into amines by borrowing hydrogen | ||||||
Author: | Hamid, Malai H. S. A. |
ISNI:
0000 0004 2673 5953
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Awarding Body: | University of Bath | ||||||
Current Institution: | University of Bath | ||||||
Date of Award: | 2008 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
This thesis describes the development of a more economical catalytic system for the N-alkylation of amines by “borrowing hydrogen” and its application in the synthesis of a variety of amines including the dopamine agonist Piribedil and the antihistamine agents Antergan and Tripelennamine. Chapter 2 describes the development of the ruthenium-catalysed N-alkylation of primary amines with primary alcohols by “borrowing hydrogen”. Chapter 3 describes the application of the ruthenium-catalysed N-alkylation of secondary amines with primary alcohols by “borrowing hydrogen”. The ruthenium-catalysed synthesis of dimethylamines by “borrowing hydrogen” is also described and a mechanistic proposal for the N-alkylation of alcohols with amines has been proposed. Chapter 4 describes the role of amines in pharmaceuticals and the ruthenium-catalysed synthesis of Piribedil, Antergan and Tripelennamine by “borrowing hydrogen”.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.501635 | DOI: | Not available | ||||
Keywords: | catalysis ; amination ; N-Alkylation ; Amines ; ruthenium | ||||||
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