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Title: New antagonists for the Kappa Opioid receptor
Author: Pillinger, Kathryn
ISNI:       0000 0004 2673 5355
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2009
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There has been much evidence in recent years to suggest that the kappa opioid receptor plays a significant role in mediating a number of behavioural disorders including drug abuse and depression. Previous in vitro evaluation within the group of secondary and tertiary amines derived from 2-amino-1,1-dimethyl-1,2,3,4-tetrahydronaphthalen-7-ol has suggested that all behave as pure opioid antagonists. These findings prompted further synthetic and pharmacological investigations of this scaffold, with the eventual aim of developing a short-acting selective kappa opioid antagonist to further probe the receptor.
Supervisor: Husbands, Stephen Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: kappa ; aminotetralin ; antagonist ; opioid