Use this URL to cite or link to this record in EThOS:
Title: The regulation of tissue inhibitors of matrix metalloproteinases (TIMPs) in the gastric epithelium
Author: Michael, Angharad Wyn
ISNI:       0000 0004 2673 4248
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
Availability of Full Text:
Access from EThOS:
Access from Institution:
The extracellular matrix (ECM) is constantly remodelled in healthy tissues; this is essential in normal physiological processes such as wound healing. Remodelling is regulated by the balanced activities of proteases and their inhibitors. An imbalance in activity can result in pathology such as fibrosis and cancer. The proteases mainly responsible for breakdown of the ECM are the matrix metalloproteinases (MMPs). They are important for normal maintenance of the 3M, but also have roles in pathophysiology. The tissue inhibitors of matrix metalloproteinases (TIMPs) are the main specific inhibitors of MM? activity. There are 4 identified human TIMPs, TIMP 1-4. Interestingly, TIMPs have roles that are independent of MMP inhibition, such as promoting cell proliferation and migration. Increased levels of TIMPs have been found in several types of cancers, including gastric cancer.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral