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Title: Balancing selection at the major histocompatibility complex (MHC) : sequence diversity and inbreeding avoidance
Author: Sherborne, Amy Louise
ISNI:       0000 0004 2673 4192
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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The major histocompatibility complex (MHC) is a much studied region of the mammalian genome because of its uniquely high level of polymorphism. Both natural and sexual selection have been implicated in the maintenance of MHC diversity. The elevated heterozygosity observed at the MHC could reflect overdominant heterozygote advantage against pathogenic infection. Equally, MHC disassortative mating would lead to an excess of heterozygotes.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral