Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501593 |
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Title: | Chemical and molecular markers of hepatic drug bioactivation, apoptosis and necrosis | ||||
Author: | Antoine, Daniel James |
ISNI:
0000 0004 2673 3237
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Awarding Body: | University of Liverpool | ||||
Current Institution: | University of Liverpool | ||||
Date of Award: | 2009 | ||||
Availability of Full Text: |
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Abstract: | |||||
Hepatotoxicity represents one of the most prevalent drug-induced adverse effects seen in the clinic and is a major cause of attrition of new chemical entities in development. Some adverse drug reactions are associated with metabolic activation to a chemically reactive intermediate. The hepatotoxicity associated with acetaminophen (APAP; paracetamol) and furosemide (FS) in mice is initiated by the formation of a reactive metabolite which has been well characterised. APAP hepatotoxicity is a major clinical problem, and with FS represents an important tool to investigate mechanisms of drug induced liver injury (DILI) in animal models.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.501593 | DOI: | Not available | ||
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