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Title: Molecular reprogramming of hepatocytes into beta-like cells
Author: Thowfeequ, Shifaan
ISNI:       0000 0004 2672 2271
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2009
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The conversion of one differentiated cell-type into another, challenges our long-held view of differentiated cells being in a fixed terminal stage of differentiation, incapable of reversal or change. Such conversions are most favourable between developmentally related cell-types such as hepatocytes from the liver and cells of the pancreas. The main drawback of culturing hepatocytes in vitro has been their limited life span and their rapid de-differentiation in culture. However, the de-differentiation of hepatocytes, and the progressive diminution in the transcription levels of liver-specific genes, is in fact associated with a concomitant induction of a pancreatic gene expression profile.
Supervisor: Slack, Jonathan ; Tosh, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available