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Title: Nicotinic acetylcholine receptors from the parasitic nematode Ascaris suum
Author: Williamson, Sally
ISNI:       0000 0004 2672 1973
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2008
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Nematodes of the genus Ascaris are large gastrointestinal parasites. Ascaris lumbricoides infects ~1 billion people globally; causing malnutrition and general morbidity, and can block the gut or bile duct causing fatal complications. Ascaris suum is a parasite of pigs; in addition to its veterinary significance, it can occasionally be zoonotic, and is a good model of the human parasite. One of the main classes of drugs used to treat parasitic nematode infections are the cholinergic anthelmintics, such as levamisole and pyrantel, which act as agonists of nicotinic acetylcholine receptors at the nematode neuromuscular junction.
Supervisor: Wolstenholme, Adrian Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: acetylcholine receptor ; two-electrode voltage clamp ; nematode ; anthelmintic ; ascaris ; nicotinic ; pyrantel ; levamisole