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Title: Crystallographic studies on a thermophile Xylanase and structural studies on anti-cancer DNA intercalators
Author: Teixeira, Susana Christina Marujo
ISNI:       0000 0004 2671 8942
Awarding Body: The University of Reading
Current Institution: University of Reading
Date of Award: 2009
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This thesis describes structural studies on a Xylanase and on DNA intercalators with anticancer properties. The first chapter introduces the molecules under study while in the second chapter the methodology is described. The third chapter describes an anisotropic refinement of the structure of Thermoascus aurantiacus Xylanase I. This glycosyl hydrolase has been studied for it has promising practical applications and its specificity and mechanism of action are not yet fully understood. The important factors lie in structural details, some of which were revealed by the model refined to 1.14A resolution. Detailed discussion of the results and related studies can be found in the two resulting publications.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available