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Title: Exploring the role of centaurin β4 in a melanoma cell line
Author: Martin, R. K.
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Melanoma is a cancer of the epidermal pigment cells, melanocytes. It is characterised by its metastatic ability and resistance to chemotherapy and radiotherapy. Centaurin β4 expression was recently shown to be upregulated in advanced stages of uveal melanoma and also in breast, colon and prostate cancer. Centaurin β4 is involved in the cyclic activation of ADP Ribosylation Factors (Arfs) which are activated at membranes. Arfs are involved in clathrin and COPI/Il vesicle formation and budding and therefore control protein trafficking between membranes. They are also involved in control of the actin cytoskeleton and their cyclic activation promotes protrusions such as invadopodia. Centaurin β4 is a multi-domain protein whose interaction with cortactin promotes invasion and metastasis specifically in tumour cells. Knock-down of centaurin β4 expression reduces invasion and motility of breast cancer cell lines sussesting an important role in carcinogenesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available