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Title: Effect of sulforaphane on neurotransmitter receptors : an insight into the regulatory networks for chemoprevention studies
Author: Mastrangelo, Lina
ISNI:       0000 0004 2670 281X
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2009
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Sulforaphane is a potent phase II enzyme inducer and well-known dietary chemopreventive agent. A proteomic study on colon adenocarcinoma Caco-2 cells was performed to detect differentially-expressed proteins following exposure to sulforaphane. Results showed that sulforaphane down-regulated the expression of serotonin receptors, decreased serotonin reuptake transporter (SERT) and upregulated nicotinic acetylcholine receptors (nAChRs), promoting signals for serotonin release. The neurotransmitter serotonin induces cellular responses by mediating G-proteins, and activating specific receptors which are important in the proliferation of colon cancer cells. These observed effects of sulforaphane on neurotransmitter receptors in Caco-2 cells may provide new insights into developing cancer prevention strategies through diet.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available