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Title: Characterisation of stem cells in the developing fetal heart
Author: Alfakir, Marah
ISNI:       0000 0004 2670 1163
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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In recent years the adult heart has gone from being thought of as a terminally differentiated organ to one with a limited regenerative capacity. The discovery of several putative cardiac stem/progenitor populations including Is11, c-Kit and side population (SP) cells, has led to the possibility of using cellular therapies to treat cardiac injury. We have previously identified SP cells from the adult mouse and human heart that are able to differentiate along a cardiac lineage. SP cells are characterised by their ability to efflux Hoechst 33342 dye due to the expression of Abcg2 (a member of the ABC transporter family). We have hypothesised that the developing fetal heart would be a stem cells rich environment and that SP cells would be present in the human fetal heart and can be isolated from it.
Supervisor: Meeson, Annette P.; Robson, Stephen C. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available