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Title: The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
Author: Farren, Matthew
ISNI:       0000 0004 2669 7029
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Rheumatoid Arthritis (RA) is one of the most prevalent inflammatory joint diseases in the developed world and 1% of the UK population is affected. Arthritis pathology is complex and is driven by pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Tumour Necrosis Factor-a. Biologics which target these cytokines have proved successful in the clinic although not all patients respond to these treatments suggesting that other pro-inflammatory cytokines are involved. Research has suggested a role for Oncostatin M (OSM) in the pathology of arthritis and studies have suggested OSM can synergise with IL-1 to promote cartilage catabolism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available